[Review] Hylamide SubQ Skin, rediscover youthful and hydrated skin

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I’ve had this product for months, but because my other NIOD’s MMHC 2 hyaluronic acid serum is too concentrated, it took me several months to finish it. As of March 2021, I can finally test SubQ Skin by Hylamide, alleluia!

The reason I’m super excited to test this serum is that it’s one of Brandon Truaxe’s, the late-CEO of DECIEM, the company behind The Ordinary, 3 favorite products. If this millionaire, who has access to the best facial care technologies globally, uses these 3 products every day, it means they are top quality! The 3 products are:

  1. CAIS 2 by Niod (I can’t live without it)
  2. MMHC 2 by Niod (I really like it)
  3. SubQ Skin by Hylamide. Brandon acknowledges that using SubQ Skin is redundant, as this serum is like the son of CAIS 2 and MMHC 2 in a less concentrated form, but he loves it so much and continues to use it.

What is SubQ Skin used for?

A highly active concentrate of advanced hyaluronic complexes, next-generation peptides, and biotechnologies to target rehydration, while improving the look of lines, wrinkles, and textural damage.

In short, it is a hydrating and anti-aging serum

Use morning and evening (2 to 3 drops for the entire face) right after cleansing and before any other treatment serum or moisturizer.

Can it be used for the eye contour: no contraindication. Even though Hylamide has a special eye serum, if you don’t have any particular problems, you can use it for your eye contour without worrying, but always accompanied by a moisturizer.


aqua (water), glycerin, hydrolyzed yeast extract, pentylene glycol, tamarindus indica seed gum, sodium hyaluronate crosspolymer, palmitoyl tripeptide-38, myristoyl nonapeptide-3, copper lysinate/prolinate, methylglucoside phosphate, hydrolyzed sodium hyaluronate, sodium hyaluronate, ahnfeltia concinna extract, saccharide isomerate, polyglucuronic acid, lactobacillus/eriodictyon californicum ferment extract, pseudoalteromonas ferment extract, phospholipids, lecithin, hydroxypropyl cyclodextrin, cetyl hydroxyethylcellulose, polyacrylate crosspolymer-6, hexylene glycol, salicylic acid, citric acid, sodium citrate, sodium hydroxide, trisodium ethylenediamine disuccinate, ethoxydiglycol, leuconostoc/radish root ferment filtrate, sodium benzoate, potassium sorbate, ethylhexylglycerin, caprylyl glycol, phenoxyethanol, chlorphenesin.

Next-generation pro-collagen Swiss technology for overall improvement in visible skin health and visible skin age. It’s not the same active ingredient found in other NIOD products (which contain copper peptides), but it’s Copper Lysinate that gives this serum its slightly turquoise color.

A novel technology that promotes better visible anti-aging results than Retinol with less irritation.

Advanced form of Matrixyl (TM of Sederma) helps to reduce the look of lines, wrinkles and surface irregularities.

Ultra-pure, non-animal-origin Hyaluronic Acid targets surface hydration and visible elasticity.
Hyaluronic acid is used to attract water. The fact that hyaluronic acid is available here with 5 molecular weights allows it to act on several skin layers.
Two forms of very-low-molecular Hyaluronic Complex act quickly to promote rehydration.
A novel Hyaluronic Acid pre-cursor helps skin look plump and healthy.
A tamarind-derived plant hyaluronic form supports immediate rehydration.

Offers lasting rehydration with continued use.
Promotes comfortable skin feel within just 2 weeks.
Improves appearance of skin texture.
Supports healthy skin barrier function.

Supports renewal and helps to prevent moisture loss.

Advanced binding agent optimizes skin exposure to active technologies for a boosted effect.

My opinion

As you can see, unlike The Ordinary, this serum is well-formulated and is not just a highly concentrated version of a single active ingredient. It can be used on its own, without any other treatment serums, as it is both humectant and anti-aging.


They use the same bottle as The Ordinary, so the cap doesn’t screw on well to the glass bottle. I’m used to it now and take care to close each bottle tightly after use. But if you are used to high-quality products, the packaging will look a little cheap.

Texture & Odor

Small discreet smell, not unpleasant, not pleasant either. The smell does not remain long.

As for the texture, since it contains hyaluronic acid, you can’t avoid that slightly slimy texture. As you can see, the serum has a slightly turquoise color, but once applied to the skin, this color disappears.

The absorption is excellent. You don’t need much for the whole face (2-3 drops). Here, I put 2 drops on my hand. That’s why the skin is shiny, but imagine the same quantity on the whole face. The serum won’t leave any trace.

Be careful. Hyaluronic acid is a humectant, which means that it draws its water from somewhere. You must always apply a moisturizer after a hyaluronic acid serum so that the humectant draws water from the moisturizer

The cream seals in the moisture. If you don’t put cream on afterward, on the contrary, the skin will be dehydrated because the serum will draw out the water already present in the skin. And when it reaches the surface, since there is no oil in the cream to prevent the water from evaporating, all that precious water will evaporate, and you will end up with wrinkled and dehydrated skin.


I still can’t comment on the anti-aging effect (fine lines and wrinkles) because I don’t have any. I’ve been moisturizing my skin so well for years, and as an Asian, I’m lucky to have fewer wrinkles than anyone else.

So I can only comment on the moisturizing effect of this serum. It is superb! My skin loves quality hyaluronic acid and knows when a hydrating serum is truly hydrating. Because it is so complete and well-formulated, I don’t need to add a second serum. So it’s perfect when I need a minimalist routine: cleanser – serum – cream.

If I need to add niacinamide, this serum can be mixed with The Ordinary’s niacinamide powder without any problems.

However, if I have to compare it to MMHC 2, I will say that MMHC 2, with 15 molecular weights of hyaluronic acid, is still much more hydrating. The skin is more supple, faster with MMHC 2 than SubQ Skin, but it’s not the same price🙂

So to be able to find such a good serum like Hylamide’s SubQ Skin for only 21€, I say GO. It’s often out of stock, so if you see it’s in stock, don’t hesitate to buy 2-3.


SubQ Skin by Hyamide, 30ml for 21€

You can buy it on the official website here (21€) or on Lookfantastic (24,95€)

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Anh est toujours très occupée à profiter de jolies choses, et à fabriquer de petites bricoles de ses propres mains. **** Hi, my name is Anh. I am a Vietnamese-French DIY passionate, beauty lover and cosmetic tester.

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